Manifold Bio is a dynamic biotech company building a pipeline of targeted biologics using a novel in vivo-centric discovery approach. Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process. This unique platform is powered by a proprietary protein barcoding technology that allows multiplexed protein quantitation at unprecedented scale and sensitivity. We combine this and other high-throughput protein engineering approaches with computational design to create antibody-like drugs and other biologics. Our world-class team of protein engineers, biologists, and computational scientists are working together to aim the platform at therapeutic opportunities where precise targeting is the key to overcoming clinical challenges.
Position
Manifold Bio is seeking an experienced Principal Scientist to lead our shuttled oligonucleotide therapeutics programs. In this role, you will serve as a dedicated scientific leader for our oligo programs, accelerating progress on key milestones while leveraging our shuttle technology for targeting peripherally administered oligonucleotide therapeutics to specific tissues and cells. You will define the strategy for expanding our oligo capabilities and organize cross-functional teams and explore external collaborations to design novel ASOs, siRNAs, and linkers, building an efficient screening and production system that leverages our ability to do multiplexed screening in vivo. As a scientific leader, you will bring strong expertise in oligo medicines to partner conversations and accelerate the discovery of oligo therapeutics by establishing efficient techniques and assays.
Responsibilities
Required Qualifications
Preferred Qualifications
This Role Might Be Perfect For You If:
You are curious, and passionate about science and drug discovery and want to work with a fast-moving team that values scientific boldness and innovation. This role requires deep technical expertise combined with a willingness to work thoughtfully and quickly to solve scientific challenges in a collaborative manner. You value an experimental approach and generating high-quality data to empower rapid, data-driven decision-making, with a commitment to meet or beat critical deadlines. You should be a team player who is also proactive and resourceful.
If you’re excited to use unique protein technologies to shape an innovative drug development strategy, build meaningful industry partnerships, and contribute directly to our mission of advancing breakthrough treatments, please apply!
We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.
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